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The oral bioavailability of quinidine compared to procainamide increased with age in both dogs and rats.I am out today so I can’t resist. The oral Papp of quinidine was also greater than that of procainamide in both species. The ratio of the oral to the intravenous Papp of quinidine was significantly greater in rats than in dogs. The largest changes were observed with the oral route of administration. The Papp values of both drugs increased with age in the dogs and rats. The in vivo Papp of quinidine and procainamide, by oral or intravenous administration, was examined in 18 clinically normal dogs and 36 rats. In seven rats, the in vitro relative permeability of quinidine to procainamide (Q/P) was 5.2 compared to 1.0 in dogs and was not significantly changed by age. Neither drug produced significant alterations in heart rate or blood pressure. In five clinically normal dogs both quinidine and procainamide were equally well absorbed by oral and intravenous routes. The effect of age on the in vitro and in vivo permeability of quinidine and procainamide was investigated in beagle dogs and rats.

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